Professor Zolt谩n Moln谩r
Biography
I earned my MD (summa cum laude) at the Albert Szent-Gy枚rgyi Medical University, Szeged, Hungary where I started my residency in Neurological Surgery in the institute of Professor Mihaly Bodosi until I moved to Oxford in 1989. I received my DPhil at the University Laboratory of Physiology in the laboratory of Professor Sir Colin Blakemore FRS studying the 鈥淢ultiple mechanisms in the establishment of thalamocortical innervation鈥 (thesis awarded the Biennial Rolleston Memorial Prize of Oxford and Cambridge Universities for 1994鈥1995). I continued my work on cerebral cortical development at Oxford as an MRC training fellow and Junior Research Fellow at Merton College. I also investigated thalamocortical development working at the Institut de Biologie Cellulaire et de Morphologie, Universit茅 de Lausanne, Switzerland, and at Kyoto Prefectural School of Medicine, Japan.聽聽
I was appointed to a University Lecturer (Assistant Professor) position at the Department of Human Anatomy and Genetics associated with a Tutorship at 好色先生TV, Oxford from 2000. I was awarded the title Professor of Developmental Neuroscience in 2007.
I am Visitor at the History of Science Museum, Oxford and I served as a member of the FENS History Committee in the past.聽Currently I am the Senior (Honorary) Treasurer of Oxford University Lawn Tennis Club ().
Previous positions held at 好色先生TV:聽Vice President (2013鈥2014); Dean for Degrees (2001鈥2006)
Teaching
I work in the Department of Physiology, Anatomy and Genetics where I am the Professor of Developmental Neuroscience. My departmental teaching contributes to the pre-clinical training of medical students. I give lectures and seminars in the 1st BM course mainly in the field of Neurosciences; on the anatomy and development of the human central nervous system. I organize the Neuroanatomy practical classes for 2nd year medical students and contribute with more specialized lectures and seminars for the FHS (3rd year medical students) and MSc Degree in Neuroscience Course. I also teach on the Principles of Clinical Anatomy Course for 3rd year medics. My college tutorial teaching includes most aspects of the human gross anatomy, histology, endocrinology and embryology.
I am very passionate about medical education.聽Through my lectures, tutorials and seminars
(150/year over 20 years) I have inspired generations of medical students at Oxford.聽I have been nominated by students for teaching awards in the past. I am the founding senior member of the . I established the History of Medical Sciences Website ().听
Research Interests
I study the development and evolution of the mammalian cerebral cortex. I am聽interested in the mechanisms of cerebral cortical neurogenesis, migration and circuit assembly, with the goal of translating these mechanisms into further understanding of human developmental conditions, such as childhood epilepsy, dyslexia, autism and schizophrenia.
My laboratory pioneered the study of the earliest transient connectivity during cerebral cortical development. I argued that the unique set of inputs and outputs plays a fundamental role in shaping the early cortical specialisation and further development. I proposed that the input to the cerebral cortex confronts corticofugal fibres at the pallial-subpallial boundary and grows over the corticofugal scaffold. My detailed studies of thalamocortical developmental abnormalities in various mutant mice provided strong support for this hypothesis.
My laboratory provided explanations for human clinical conditions by identifying key cortical developmental mechanisms, such as neurogenesis and migration. My laboratory demonstrated that developmental gene expression in the early-generated and largely transient cortical subplate neurons overlaps significantly with gene networks that have been specifically linked to the pathogenesis of schizophrenia and autism.
My laboratory has made contributions to the understanding of brain evolution. With comparisons in metatherian and eutherian mammals I established that the subventricular zone, with its intermediate progenitors, is a key developmental milestone in the formation of a six-layered mammalian neocortex. My laboratory has identified cortical progenitors whose neurogenesis is delayed, and which contribute only to callosally-projecting upper cortical layers. Remarkably, these progenitors are not present in the avian brain.聽My聽laboratory identified transcriptomic networks in mammalian and avian brain and found evidence of thalamic recipient cells in cortical layer 4 in mammals and the nidopallium in birds: both express similar gene networks, in spite of having different embryonic origin.聽
Visit my departmental research group page for further information at:
What inspired me?
Early inspirations to engage in medical research must have come from visits to the kitchen where I helped my mum to prepare chicken for cooking.聽 I spent hours looking at the internal organs and trying to figure out how it might all work.聽 Later I talked a lot to my brothers Elek and B茅la (who also became medical doctors) and read history of medical sciences books and watched television programmes, such as Delta, or live lectures by J谩nos Szent谩gothay on Hungarian television.聽 I was inspired by my schoolteachers at the Arany J谩nos Secondary School in Nagyk枚ros, Hungary who fuelled my interest in chemistry (Etelka R贸zs谩s), biology (L谩szl贸 Kis) and later in neuroscience (George Benedek and Mih谩ly Bodosi, Albert Szent-Gy枚rgyi Medical School, Szeged, Hungary and Colin Blakemore University of Oxford, UK).听 I can never be grateful enough for their unconditional trust and support. Now I get inspiration from my own students and postdoctoral fellows and colleagues at the department and at 好色先生TV鈥檚 College.聽 I enjoy discussions at tutorials where some of the students with fresh minds come up with the most original and unusual ideas that should be taken seriously and examined further.
Selected publications
The Molnar laboratory published over 15 papers during the 2024/25 academic year:
Test, agy, viselked茅s - H谩rom n茅zet 茅s egy besz茅lget茅s.
Hungarian translation of: Tamas Horvath, Joy Hirsh, Zolt谩n Moln谩r (2022) Body, Brain, Behavior - Three Views and a Conversation ELSEVIER, Academic Press, An imprint of Elsevier, 1st Edition - February 1, 2022 isbn:9780128180938.
Hoerder-Suabedissen A, Moln谩r Z (2015) Nature Reviews Neuroscience. 16(3):133-46.
Garc铆a-Moreno F, Moln谩r Z听(2015) Proc Natl Acad Sci U S A. 112(36):E5058-67.
Bakken TE, Miller JA, Ding S-L, Sunkin SM, Hevner RF, Moln谩r Z, Phillips JW, Dang C, Jones AR, Amaral DG, Bernard A, Lein ES (2016) . Nature, 535(7612):367-375.
Lein ES, Belgard TG, Hawrylycz M, Moln谩r Z听(2017) Annu Rev Neurosci. 40:629-652.
Garc铆a-Moreno F, Anderton E, Jankowska M, Begbie J, Manuel Encinas J, Irimia M, Moln谩r Z (2018) Cell Reports 22, 96鈥109
Awards and distinctions
2025 Elected External Member of the Hungarian Academy of Sciences
2025 Invited Visiting Professor at Tokyo Metropolitan Institute of Medical Sciences, Tokyo, Japan (March/May)
2024 Elected Member of EMBO (European Molecular Biology Organisation)
2024-2026 Einstein Visiting Fellowship at the Charit茅 鈥 Universit盲tsmedizin Berlin renewed for a further two years (2020-2026)
2020-24聽 Einstein Visiting Fellow at Charit茅-Universit盲tsmedizin Berlin, Germany
2019聽 聽Elected Member of Academia Europaea (Physiology and Neuroscience)
2018聽聽聽Elected member to the聽European Neonatal Brain Club聽(society involved in the study of neonatal brain)
2018聽 聽Elected聽Fellow of the Anatomical Society; Elected聽鈥淣ew Fellow of the Year 2018鈥
2015聽聽聽Allan & Maria Myers International Visiting Fellowship, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia
2012聽聽聽Elected聽Member of 鈥淐ircle of Willis鈥澛燗ssociation of medical teachers at Oxford
2010聽聽聽Medical Sciences聽Teaching Excellence Award, University of Oxford
2006聽聽聽Elected聽Member of 鈥淏undle of His鈥澛燗ssociation of medical teachers at Oxford
1999聽 聽Krieg Cortical Kudos Cortical Explorer Prize聽of the American Anatomical Society's Cajal Club
1995聽 聽Biennial聽Rolleston Memorial Prize of Oxford and Cambridge Universities聽for 1994鈥1995 (given for the best DPhil thesis)
1988聽 聽The聽Istv谩n Ap谩thy Medal聽of the Albert Szent-Gy枚rgyi Medical University, Szeged, Hungary
1981聽 聽The 1981聽Arany J谩nos Prize聽of the Arany J谩nos Gimn谩zium, Nagyk枚r枚s, Hungary
Meetings Organised
2025 Cortical Development, Neural Stem Cells to Neural Circuits, Giardini Naxos, Sicily, Italy (co-organized with Arnold R. Kriegstein, Gordon Fishell, Flora Vaccarino) -
2025 Human Cerebral Cortex Development III. Summer Meeting of the Anatomical Society, 14-16th July 2025, 好色先生TV鈥檚 College, Oxford (co-chair with Gavin Clowry) -